Depression might be associated with accelerated cellular aging. However, does this result in an irreversible state or is the body able to slow down or recover from such a process? Telomeres are DNA‐protein complexes that protect the ends of chromosomes and generally shorten with age; and therefore index cellular aging. The majority of studies indicate that persons with depression have shorter leukocyte telomeres than similarly aged non‐depressed persons, which may contribute to the observed unfavorable somatic health outcomes in the depressed (...) population. Some small‐scale preliminary studies raise the possibility that behavioral or pharmacological interventions may either slow down or else reverse this accelerated telomere shortening, possibly through increasing the activity of the telomere‐lengthening enzyme telomerase. This paper covers the current state of evidence in the relationship between depression and the telomere‐telomerase system and debates whether depression‐related cellular aging should be considered a reversible process or permanent damage. (shrink)

Burgess, J.P. and Rosen, G. Subject with No ObjectElliott, R.Faking Nature.

There are fresh currents running through this volume, subtitled "An Essay on Truth," which dispel some accumulated but unexamined theories: e.g., that St. Paul took literally the three-story picture of the world; that nature can be subsumed under the category of history so that all meaning is historical; that there is a genuine dilemma between absolutism and relativism in morality. The author argues that the clue to reality is "story" for the simple reason that reality itself is story: a dramatic (...) conflict between persons, ambiguous at its core. The real then is grasped as story, rather than in terms of philosophical Weltanschauung, or scientific Weltbild, or history which in furnishing elements to the story distinguishes it from myth. Beyond emotive propositions, verbal propositions, and descriptive propositions lies a fourth kind of statement proper to story. Unfortunate oversimplifications compromise the book’s thesis: e.g. that Logos, Substance, and Life-Process are concepts whose use is metaphorical as is that of causality; that Aquinas taught grace is a supernatural substance; that Aristotle viewed reality as ideal rather than actual; that to conceive of evil as non-being is to deny it reality, to view it as illusory. At work here is a decided antipathy to the narrowings of rational discourse that rules out anything that might undergird the author’s "story" and give it ontological density. (shrink)